|Innovative, integrative tools & methods for exposure assessment
A large part of the global burden of diseases remains unexplained and may be at least partly explained by multiple exogenous factors including environmental pollutants.
The exposome has been proposed as a new paradigm to encompass the entire human exposures by providing a comprehensive description of lifelong exposure history. What is now required is to ensure that the exposome is translated from concept to utility for better delineating the causes and prevention of human diseases.
There are numerous and large challenges in assessing human environmental exposures for a workable approach in both epidemiological research and risk management. These include: i) the accurate and reliable measurement of many agents/substances at low doses in the external environments (multiple sources, media and pathways), ii) addressing interactions that can add or potentialize their effects, iii) the measurement of a wide range of biological responses in the internal environment, iv) addressing the exposure assessment to complex mixtures, v) addressing the dynamic lifetime exposures with critical windows, vi) the interactions of such exposures with social, contextual and individuals determinants …
EDCEH 2016 offers an attractive program covering important topics about the challenges of exposure assessment throughout human life and provides a holistic view of environmental exposure assessment approaches: new technologies to trace exposure history, including in early life (conception, pregnancy, infancy and childhood), innovative methods to characterize multiple stressors, integrative approaches combining high-throughput analyses and systems biology.